Creatinine Clearance (eGFR) Calculator

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Creatinine Clearance and eGFR Calculator

What is Creatinine Clearance and eGFR?

Creatinine clearance and estimated glomerular filtration rate (eGFR) are measures of kidney function. Creatinine clearance estimates the rate at which kidneys filter blood, while eGFR provides a normalized assessment based on demographics and biomarkers, such as serum creatinine and cystatin C.

Why are these calculations important?

Assessing kidney function is vital for diagnosing and monitoring chronic kidney disease (CKD). Creatinine clearance and eGFR help detect early signs of kidney impairment, guide treatment decisions, and ensure proper medication dosing.

How are Creatinine Clearance and eGFR calculated?

The calculation involves the following formulas:

  • Cockcroft-Gault Equation: Estimates creatinine clearance using age, weight, gender, and serum creatinine levels.
  • MDRD Formula: Calculates eGFR using serum creatinine, age, gender, and ethnicity.
  • CKD-EPI Cystatin C Equation: Determines eGFR using serum cystatin C levels, age, and gender.
  • Combined CKD-EPI Equation: Combines creatinine and cystatin C for more accurate eGFR estimation.

Normalization for body surface area (BSA) ensures eGFR comparisons across individuals of different sizes.

Cockcroft-Gault:
  CrCl = ((140 - Age) × Weight × Gender Constant) / Serum Creatinine

MDRD Formula:
  eGFR = 186 × Serum Creatinine^(-1.154) × Age^(-0.203) × Adjustment Factors

CKD-EPI Cystatin C:
  eGFR = 133 × Cystatin C Factors × Age Adjustment × Gender Factor

Example Calculation

Inputs:
  Gender: Male
  Age: 30
  Serum Creatinine: 1.1 mg/dL
  Serum Cystatin C: 0.9 mg/L
  Standardized Assays: Yes
  Adjust for Body Surface Area: No

Calculations:
  Serum Creatinine (mg/dL): 1.10
  CKD-EPI Cystatin C eGFR = 87.34 mL/min/1.73 m²
  Combined eGFR = 88.70 mL/min/1.73 m²

Result:
  Kidney Function: Normal

FAQs

What does a low eGFR indicate?

A low eGFR suggests impaired kidney function, which may indicate chronic kidney disease (CKD). Further evaluation and intervention may be required.

Why use cystatin C for eGFR estimation?

Cystatin C is less influenced by factors like muscle mass and diet, making it more reliable for estimating kidney function in some patients.

How is kidney function classified?

Kidney function is classified as normal, mildly reduced, or significantly impaired based on eGFR thresholds (e.g., >90 mL/min/1.73 m² for normal function).

**Disclaimer:** These health calculators are for informational purposes only and do not replace professional medical advice. Results may not be 100% accurate for all individuals. Always consult a healthcare professional before making any health decisions.

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